Universidad de Zaragoza (UNIZAR) was founded in 1542. Since that date, UNIZAR has continuously grown, adding Engineering to its Degrees in the early Seventies. Nowadays UNIZAR, with more than 40.000 students and 2.293 high quality researchers belonging to 202 research groups, occupies a very good position among National and European Universities.

Part of the research activity of UNIZAR is developed within five Research Institutes. One of them, Aragón Institute of Engineering Research (I3A), will host the research activity of CAD-BONE.

The regional Government of Aragón established the I3A on May 14, 2002 and it was the first Institute at UNIZAR. Recognising the importance of synergies and multidisciplinarity, the research interests of the Institute are deliberately multifield and multidepartamental, searching for technological solutions for the future by promoting innovation and excellence.

The Institute has 32 research groups, one of them is M2BE-Multiscale in Mechanical and Biological Engineering (officially registered as Applied Quality Research Group by the Regional Government of Aragón). The group lectures at the Higher Polytechnic Engineering School and the University School for Technical Industrial Engineers and participates in the Doctoral Programs in Biomedical Engineering and Applied Mechanics.

Its members participate actively in R&D projects, conferences, courses, seminars, promoting collaborations and coordinating projects with other groups from their national, European and international networks. The team also has numerous publications in prestigious international journals.

M2BE main research activity is focused in the Computational Mechanobiology field. Mechanobiology combines different aspects of the Mechanical Engineering with the Biological Engineering. Due to the previous experience of the members of the M2BE group, we mainly focused the research on the use and development of computational models. For their validation we work in collaboration with experimental groups (national and international ones). Physicians within the team provide the clinical and biological meaning of the simulated problems. The research activity of the group is structured, on one hand, on the multiple space scales that define an engineering problem, and on the other hand, in the different applications in which we are working. Therefore, from the methodological point of view of the Multiscale Engineering, the different scales in which we are working are:

  • Global or macroscopic scale in which the engineering or biomechanical problem is defined.
  • Tissue or material scale which is related with the modelling of the material or tissue behavior.
  • Micro- or nano-scale where all the important aspects that composed the material or tissues are integrated.

On the other hand, the engineering applications where we are currently working are:

  • Mechanobiology of the regeneration and tissue remodelling
  • Cellular Mechanobiology
  • Tissue Engineering
  • Computational evaluation of prosthesis and implants design
  • Design of biomimetic or self-healing materials in different engineering applications



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