Combining biomechanical models and bone remodelling/healing algorithms with the current image analysis tools provided by MATERIALISE software is crucial to the development of a new generation of virtual simulations for clinical applications. CAD-BONE will provide a useful and practical predictive tool to estimate the short and long-term bone response after surgical intervention. Current computer systems are mainly focused on surgery planning, but they do not consider the long-term results of the treatment. The S&T objectives of the CAD-BONE proposal can only be successfully achieved by means of an interdisciplinary consortium and the most adequate transfer of knowledge. It encompasses very different areas of expertise (medical image analysis, FEA, biomechanical and mechanobiological models) which are very rarely found in a single group or institution. In particular, each CAD-BONE partner has an excellent research record in at least one key area of the project:

UNIZAR: more than 10 years of experience developing FE-based models in different bone tissue applications (remodelling, healing, morphogenesis, distraction, bone tissue engineering, etc.) with numerous international and recognised scientific contributions.

KU LEUVEN: long standing expertise in numerical and experimental analysis of human tissues and their function covering the broad spectrum of length scales in human body: from cell to tissues and from organs to the entire body including its interaction with environment, mainly focused on four themes: bone and implant mechanics, mechanobiology and tissue engineering, computer-aided surgery, and functional biomechanical design and analysis. Many projects run in collaboration with clinical partners.

MATERIALISE: 20 years of experience in innovative software development and research for 3D imaging and surgical planning software, such as Mimics, Surgicase CMF and Surgicase Orthopaedics. Materialise will provide know-how and expertise regarding image processing and analysis.


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