The main objective of CAD-BONE is to perform a multidisciplinary research that will result in technology that will radically improve the development of patient-specific computer models for the modelling of bone adaptation/healing after prosthesis implantation in different bone treatments: musculoskeletal and orthodontic applications. Therefore, the final aim of CAD-BONE is to demonstrate the feasibility of integrating patient specific modelling, musculoskeletal loading, and simulation of adaptive bone remodeling to simulate functional outcome of patient treatments. This will have a relevant impact in 1) European industry (the development of software for surgery planning, diagnostic and design of treatments), 2) academia (by advancing the state of the art in the role of mechanical factors in bone remodelling and healing) and 3) clinicians (a predictive tool for assessment of short and long-term bone response after surgical interventions).

This multidisciplinary approach will allow the achievement of the following complementary specific objectives, which will go substantially beyond current state-of the-art:

Objective 1: Development of patient-specific FE models: Integration of different computer technologies with a predictive role.

Objective 2: Quantification and verification of CAD-BONE multidisciplinar computer approach of bone remodelling/healing models.

Objective 3: Predictive computer simulations to estimate bone response after surgical intervention.

Next figure shows CAD-BONE scheme in relation to its objectives:

All these CAD-BONE objectives can only be achieved by means of a well-balanced consortium, where each partner is a key actor in their respective fields of expertise and an adequate transfer of knowledge among them. CAD-BONE consortium is made up of two academic institutions and one company from two different European countries. MATERIALISE will contribute with its ample commercial experience in Industrial Services (Rapid Prototiping and Manufacturing), medical image analysis and clinical applications in multiple surgery planning. The academic institutions (UNIZAR and KU LEUVEN), will bring a combined expertise in the field of Finite Element Analysis (FEA), specially focused on the development of biomechanical and mechanobiological models for bone tissue. Thus the participation of the two sectors is well covered and will allow each sector to benefit from the experience, the advanced knowledge and the culture (mission and vision) of the other one.



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